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INVESTIGATING ORAL LESION PATHOGENESIS: THE ROLES OF TOBACCO, ALCOHOL, AND NUTRITIONAL DEFICIENCIES
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This study investigates the etiological factors, clinical presentation, and prevalence of various types of oral lesions in a cohort of 100 patients presenting with ulcerative, membranous, and ulcero-membranous lesions at a Teaching and General Hospital in India. The oral lesions were analyzed by site, secondary involvement, and lesion type, with particular attention to lifestyle factors such as tobacco and alcohol use, nutritional status, and oral hygiene. Results showed a high incidence of malignant ulcers primarily in the tongue and buccal mucosa, sites commonly associated with tobacco placement. Secondary involvement was observed in 22.4% of cases, with the lymph nodes and mandibular bone being the most common sites. Ulcerative lesions were the most prevalent across all lesion types, predominantly benign in nature, while premalignant and malignant cases exhibited ulcerative and ulcero-membranous characteristics. The findings underscore the multifactorial etiology of oral lesions, highlighting tobacco, alcohol, nutritional deficiencies, poor oral hygiene, and chronic irritation as significant risk factors. This study emphasizes the need for preventive strategies, including lifestyle modifications, nutritional interventions, and dental care, to mitigate risk factors for oral lesions. Enhanced public awareness and early intervention, particularly among high-risk groups, are crucial for reducing the incidence and improving outcomes in oral disease managementddd