| Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting 10-15% of women of reproductive age,
characterized by reproductive, cosmetic, and metabolic disturbances. This study aimed to evaluate the serum homocysteine
(Hcy) levels, lipid profiles, and their association in PCOS patients to understand their role in cardiovascular risk. A total of
100 female participants, including 50 PCOS patients and 50 age-matched healthy controls, were recruited. Blood samples
were analyzed for Hcy, total cholesterol, triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein
(LDL), and very low-density lipoprotein (VLDL). Statistical analysis was conducted using Student's t-test and Pearson's
correlation, with a p-value of ?0.05 considered significant.The study found that PCOS patients had significantly higher
levels of Hcy (11.87±5.14 ?mol/L), total cholesterol (313.5±70.42 mg/dL), TG (207.18±84.46 mg/dL), LDL
(236.06±67.99 mg/dL), and VLDL (41.46±16.79 mg/dL), along with lower HDL levels (35.98±13.81 mg/dL), compared to
controls. A significant positive correlation was observed between Hcy and total cholesterol (r=0.36, p=0.01) and Hcy and
LDL (r=0.29, p=0.04). These findings suggest that elevated Hcy levels and dyslipidemia are major risk factors for
cardiovascular diseases (CVD) and type II diabetes mellitus in PCOS patients.The study recommends routine screening of
serum Hcy levels and lipid profiles in the clinical management of PCOS to assess cardiovascular risk. Additionally, further
research is warranted to explore the correlation between Hcy levels, vitamin B12, folic acid concentrations, and their
potential role in mitigating cardiovascular risks in PCOS patientsddd |
