| This cross-sectional study examines antibiotic-related Adverse Drug Reactions (ADRs) in 250 individuals, aiming to
elucidate demographics, distribution patterns, and severity levels associated with these reactions.Patient information,
including age, gender, and ADR details, was recorded in detail. The WHO's causation assessment categorized ADR
certainty. Data analysis included breakdowns based on age groups, antibiotic classes, administration routes, and affected
organ systems.The diverse cohort (132 males, 118 females) showed young adults (30-45 years) constituting 27%.
Predominant ADR contributors were ?-lactams (32.8%), followed by sulfonamides, macrolides, and fluoroquinolones.
Outpatient settings reported higher ADR incidence (84.8%) than indoor patients (15.2%). Oral antibacterials caused 89%
of ADRs, with most (72%) within the first three days.The gastrointestinal tract (58.6%) was most affected, with prominent
cutaneous presentations (33.3%), especially itching and rash. Hypersensitivity responses were notably associated with
sulphonamides. ADR intensity categorization revealed 60.8% moderate, 35.6% mild and 4.4% severe ADRs.This study
offers a comprehensive overview of antibiotic-related ADRs, emphasizing demographic distribution, causative agents, and
clinical manifestations. Findings underscore the need for vigilant monitoring, particularly in outpatient settings, providing
valuable insights for healthcare professionals managing and preventing antibiotic-related ADRsddd |
