| Psoriasis is a chronic inflammatory skin disorder that presents unique therapeutic challenges, particularly in its localized
plaque form. The 308 nm excimer laser has emerged as an effective treatment option for localized plaque psoriasis,
offering targeted ultraviolet B (UVB) therapy. However, the relative efficacy of excimer laser monotherapy compared to
combination therapy with topical agents remains unclear. This comparative study aims to evaluate the effectiveness of
excimer laser monotherapy versus combination therapy with topical corticosteroids in the treatment of localized plaque
psoriasis. A total of 100 patients diagnosed with localized plaque psoriasis were enrolled in the study and divided into two
groups. Group 1 received excimer laser monotherapy, while Group 2 received a combination of excimer laser therapy and
topical medications, including Mometasone furoate 0.1% and Fluocinolone acetonide 0.025%. Photographic evaluations
were conducted every two weeks, and treatment outcomes were assessed based on lesion clearance and symptom
improvement. Results indicated that 30 out of 50 patients in the monotherapy group showed significant improvement after
4 weeks, while 40 out of 50 patients in the combination therapy group exhibited improvements within 2-3 weeks. The
combination therapy was found to be more effective in accelerating lesion clearance and enhancing symptom relief.
Despite some limitations, such as resistance in hand and foot lesions, the study concludes that combination therapy with
excimer laser and topical agents offers superior outcomes compared to monotherapy for localized plaque psoriasisddd |
