| Insulin resistance, a common feature of polycystic ovarian syndrome (PCOS), is often associated with
hyperhomocysteinemia. This prospective study conducted at university-affiliated in vitro fertility clinics aimed to assess
homocysteine, insulin, and blood glucose levels in women with and without PCOS. Blood samples were collected from 64
women with PCOS and 50 without, on the third day of their menstrual cycles. Using HOMA-IR and fasting glucose to
insulin ratios, insulin resistance levels were compared between the groups. Analysis revealed significantly higher
homocysteine levels in PCOS patients compared to controls, particularly among those with insulin resistance (p-value =
0.02). Additionally, fasting insulin and glucose levels were elevated in the insulin-resistant group (p-value = 0.001). These
findings suggest a correlation between insulin resistance and hyperhomocysteinemia in PCOS patients, emphasizing the
importance of monitoring these metabolic parameters in clinical management.ddd |
