| The thyroid gland plays a crucial role in maintaining body homeostasis, and its proper function is vital for good health.
Long-term space missions have revealed that mice exhibit heightened sensitivity to hypogravity, particularly in thyroid
tissue. Physiological deconditioning resulting from extended spaceflight can be mitigated through exposure to
hypergravity. In this study, various lipids and proteins associated with thyroid tissue function were evaluated following
hypergravity treatment. Analysis included quantification of chemoglobulin (CHO), different sphingomyelin (SM) and
ceramide species, cAMP, caveolin-1, thyrotropin (TSH) receptor, as well as signaling molecules STAT3 and TH, and
cholesterol (CHO). Results indicated that after hypergravity exposure, caveolin-1 and TSH receptor expression increased,
while STAT3 levels decreased. Interestingly, cAMP levels remained unaffected. Additionally, TSH receptor subunits were
shed and dispersed throughout the cell membrane upon TSH treatment. While no significant differences were observed in
SM and ceramide species, a noteworthy finding was the substantial reduction in CHO levels. This study underscores the
impact of hypergravity on CHO and TSH receptor dynamics within the thyroid gland, suggesting that hypergravity-induced
CHO depletion may disrupt TSH-TSH receptor interactions, leading to significant alterations in lipid rafts.
Key words: Thyroid gland, Hypergravity, Lipid rafts, TSH receptor, Spaceflight effectsddd |
