| Patients with Parkinson's disease (PD) commonly exhibit these symptoms olfactory involvement. With the help of different
types and concentrations of odorants, we conducted a quantitative study to examine the function of smell in people with
Parkinson's disease. In this study, we sought to determine whether a particular odour can influence PD patients' severity
and duration. Study participants included 89 patients with nondemented PD and 20 other patients with similar age profiles.
Tests using T and T olfactometers were used to assess smell function quantitatively. Various concentrations of five types of
odorants are used in this test. Hoehn and Yale (HY) patients with Parkinson's disease in five groups stages I (n = 24), II (n
= 48), III (n = 86), and IV (n = 20) and 40 controls (n = 40) performed odor recognition thresholds (RT) for all five
odorants and for each individual odor. In order to compare the five groups, one-way analysis of variance was used as well
as Ryan's method. A significant difference was found Comparison of the total RT scores of HY II, III, and IV patients with
those of controls and HY I patients. HT I and control were no statistically significant differences between the groups in RT
scores. In contrast, three patients from HY I (25%) had total RT scores over two standard deviations above the mean of the
controls. The RT scores for methylcyclopentenolone and skatol are significantly higher when compared with HY II, III,
and IV patients and controls. In comparison with control subjects, PD patients did not exhibit any statistically significant
differences in these three odorants. Based on the present study, hyposmia became more common in PD patients as they
progressed through HY II. Olfactory Parkinson's disease patients' evaluation was improved with methyl cyclopentenolone
or skatol as a single odorant. It was also confirmed that some patients with HY I had olfactory deficits. It is important to
continue to study prospectively HY I patients with hyposmia to determine if they have a different profile of PDddd |
