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ACUTE HIV INFECTION IN PREGNANCY: THE CASE FOR RESCREENING IN THE THIRD TRIMESTER
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Testing against HIV is both sensitive and specific to diagnosing existing HIV-1 infection but it is unable to detect acute HIV infection (AHI). AHI has an exceptionally high level of viral load, which can imply a greater risk of vertical or horizontal transmission. In this way an intervention can limit transmission via early detection of AHI. It may be difficult, however, to recognise AHI, as there may be no symptoms or ambiguous; therefore AHI, especially during pregnancy, is commonly neglected. There is a case report of AHI with headache and fever in a pregnant lady. In the first trimester and during the period of AHI, Anti-HIV Elisa confirmed her to be HIV negative 26 3/7 weeks ago, yet she had an HIV RNA viral load of 434 000 copies/mL diagnosed. A 23-year-old headache G1P0 presented to the emergency department (ED) of a private hospital for 26 weeks and three days of gestation. She had persistent hypertension, depression, anxiety and uterine fibroids in her medical history. Her four-week history was pregnant with obstetrics and sometimes stomach upsets she was diagnosed with laparoscopy that only revealed the rented corpus luteum. This case study emphasises the constant concern about the current HIV testing recommendations and problems in the recognition and diagnosis of acute HIV infection for women who are pregnant. In its early phases, obstetricians have to be able to detect and know how to diagnose HIV infection. In the case study, the chronology of HIV infection from initial exposure to antigens HIV-1 and the consequences of early detection of the disease are emphasised. In the context of acute HIV-infection seronegative phase, we support guidelines for the testing of viral reflexes of every pregnancy sequencing. An increased risk of HIV infection while pregnant leads us to suggest a recreation of HIV-1 in all women who are pregnant irrespective of their risk factors, due to hormone changes and cases where HIV-1 negative women are tested early in their pregnancy, giving rise to positive babies soon after they are born. Further testing during pregnancy would allow the use of vertical transmission methods for women and unborn offspring.More cost-benefit analyses may be helpful to evaluate repeat tests in the United States. In addition to rapid screening, the use of pooled ser detection approaches can decrease increased costs for assessing viral loadddd