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EFFECT OF TREATMENT WITH LOW DOSE CORTICOSTEROIDS ON MORTALITY IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK
Article Information
Language English
Corres.Author Dr.T.Akhila sai
Email akhila199429@gmail.com
Accepted Date 2020-09-23 12:54:35
File size 443.44 KB
No of Downloads 687
Published by www.ijcpcr.com
Full Text
The benefit and use of low dose corticosteroids in reduction of mortality in patients with severe sepsis and septic shock. Septic shock may be associated with relative adrenal insufficiency. Thus, replacement therapy with low dose steroids has been proposed to treat septic shock. Surviving sepsis guidelines suggests low dose steroids use for septic shock patients poorly responsive to fluid resuscitation and vasopressor therapy. Objective: To assess whether treatment with low dose steroids (hydrocortisone and fludrocortisone) reduce 28 day mortality in patients with severe sepsis and septic shock. Treatment: patients were divided into two groups randomly. Group 1(placebo group) received only conventional therapy(fluids and vasopressors) and group 2 (steroids) received Hydrocortisone intravenously every 6 hours as 50mg bolus and one tablet containing 50mcg of 9-?-fludrocortisone for 7 days. Results: 150 patients were included in analysis (75 in placebo group and 75 in steroid groups) 28 day mortality in placebo group was 60.5% and in steroids group was 54.6%. ICU mortality in placebo group was 66.6% and in steroid group was 60%.Hospital mortality in placebo group was 69.3% and in steroid group was 63.5%. Conclusion: Treatment with low dose corticosteroids significantly reduced 28 days mortality in patients with severe sepsis and septic shock.ddd