| Chemotherapy is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen. This means chemotherapy can kill cancer cells that have spread (metastasized) to parts of the body far away from the original (primary) tumor. Receptors for a number of neurotransmitters with potentially important roles in the emetic response are present in the dorsal vagal complex. These include the neurokinin-1, 5-HT3, and dopamine-2 receptors, which bind to substance P, 5-HT, and dopamine, respectively. 56 patients of the total number of 150 subjects underwent concurrent radiation therapy. Among the patients who received concurrent chemo-radiation, n=32(21.3%) were given OPD regimen, n=17(12.5%) were given APD regimen and n=7(4.7%) received APOD regimen. More number of patients with chemotherapy alone received complete response to anti-emetic regimen. Patients taking very highly emetogenic chemotherapy were n=11(7.3%) followed by highly emetogenic chemotherapy 101(67.3%) and moderately emetogenic chemotherapy 38(25.3%). In this observational study, no significant difference was observed between olanzapine and aprepitant in preventing nausea and emesis induced by highly and moderately emetogenic chemotherapy. Olanzapine can improve the complete response of acute and delayed, nausea and vomiting when compared with the standard therapy of anti-emesis. Thus Olanzapine has been shown to be safe and effective agent for the prevention of CINV, especially in delayed phase. It is also a highly cost effective drug compared with 5HT3 serotonin antagonist and NK1 antagonists. Thus we suggest olanzapine is a good choice for prophylactic treatment in chemotherapyddd |
