| Transdermal patches of Tramadol hydrochloride were prepared by the synthetic polymers HPMC, PVA, combination of HPMC and PVA. The patches were transparent, smooth andflexible. The preformulation studies involving description, solubility, melting point, partition coefficient of the drug were found to be comparable with the standard. Based on the all the above preformulation studies the drug was suitable for making the transdermal formulation up to 12 hrs when compared to formulations F1 and F2. From the percentage inhibition values obtained from anti-inflammatory studies, the decreasing order for the anti-inflammation can be given as: F3.So it was concluded that the F1 >F2 >F3.ddd |
