ABSTRACT

The leaves of Barringtonia acutangula is used traditional Indian medicine to treat epilepsy. In present study the effect of aqueous extract of Barringtonia acutangula (EBA) on antioxidant enzymes in rat brain after induction of epilepsy by PTZ were observed. In which Superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase was significantly (P<0.01) decreased in rat brain due to epilepsy and it was significantly (P<0.01) restored by administration of aqueous extract of Barringtonia acutangula treated rats. Similar dose dependent results were obtained in PTZ model also. Whereas EBA significantly decreased lipid peroxidation in PTZ model. The anticonvulsant activity of EBA might be presents of antioxidant properties and it delays the generation of free radical in PTZ induced epilepsy.

Key words: Antioxidant enzymes, Barringtonia acutangula L, Superoxide Dismutase, Glutathione Peroxidase, Glutathione Reductase; Catalase, Lipid peroxidation.