ABSTRACT

Topical gel of NSAIDs is very useful as palliative product for treating pain and inflammation associated with arthritis. Various synthetic, semi synthetic and natural gelling agents are used with literature suggesting their safety & suitability for topical use. For the present study the gel which are prepared by using different type of polymer carbopol 940(CP), Hydroxy Propyl Methyl Cellulose (HPMC) K4M and xanthan gum were chosen with cyclodextrin (CD)as a penetration enhancers. The prepared gel was evaluated with different parameters such as pH, Homogeneity, Viscosity, Spreadability, drug content, pharmacological evaluation like carrageenan induced rat paw edema, skin irritation study, In-vitro diffusion study and Stability studies. The results of the present study showed that the permeation rate of formulation C3 and C4 was enhanced without any significant change in the pH, Viscosity, Spreadability and drug content. The formulations C4 have good significant level during anti-inflammatory study.

Key words: Ketoprofen, Rat paw oedema, gel, Carbopol 940, HPMC K4M, Xanthan.