ABSTRACT

                Doxofylline is a new generation methyl xanthine derivative used to treat asthma. Doxofylline belongs to a group of medicines known as phosphodiesterase inhibitors. Doxofylline have decreased affinity towards adenosine A1 and A2 receptors, which may account for better safety profile of drug. The aim of present work was to formulate and evaluate sustained release tablets of Doxofylline by using hydrophilic polymers such as HPMC K100M and HPMC K15M in different ratios. Drug-excepients interactions were studied by FTIR. Different sustained release granules were prepared by slugging and wet granulation methods, the granules were evaluated for their derived properties and flow properties. The prepared granules were compressed by using rotary tablet punching machine and evaluated for weight variation, assay, In-vitro drug release profile and stability. In-vitro drug release studies were compared among the different SR formulations and F7 releases 98.85% of drug at the end of 12^th hour and were considered as a best formulation. The obtained data was fitted into different kinetic models and the formulation F7 was best explained Peppas kinetic model. The release was follows Non-Fickian diffusion transport mechanism.

Key words: Doxofylline, Asthma, HPMC K100M, Sustained release tablets, In-vitro drug release, Drug release kinetics.