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THREE CASE REPORTS OF 5-FLUOROURACIL INDUCED SERPENTINE SUPRAVENOUS HYPERPIGMENTATION

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 ABSTRACT

The toxicity of the 5-fluorouracil is strongly influence by the dosage used, the rate and duration of drug administration. However, common side effects of 5-fluorouracil include nausea, vomiting and diarrhoea, leucopenia and thrombocytopenia. We report two cases with inoperable carcinoma of stomach who developed serpentine supravenous hyperpigmentation at the 4th cycle of chemotherapy.

 

Key words: Chemotherapy, Cancer, Cell-cycle, Dark streak.

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