ABSTRACT

The present investigation deals with development of mucoadhesive thermosensitive pluronic lecithin organogel of miconazole nitrate for vaginal candidasis. To develop more effective treatment for vaginal candidasis, Miconazole 1% (MZN) was formulated as pluronic lecithin organogel (PLOs). Total of  8 formulation have been formulated F1-F8 by keeping the soya lecithin as constant upto 4%  for all the formulation and then changing  the concentration of carbopol 934 and pluronic f 127(by keeping carbopol 934  0.2% and pluronic f 127 15%-50%  from F1-F4 and carbopol 934 0.8% and pluronic f 27 15%-50%  from F5 to F8). For all the PLOs formulations composed of miconazole nitrate (1%), Spreadability, rheological behaviour, drug content (%), mucoadhesive force, gelling capacity and in-vitro release profiles of the different formulations were determined. In vivo antifungal activity of MZN, tested against Candida albicans vaginitis in agar plate, was significantly prolonged after vaginal delivery using PLOs. These results indicate that MZN-containing F4 formulation of vaginal PLOs are safe, convenient and provide effective treatment of vaginal candidasis with reduced dosing interval.

Key words: Vaginal candidasis, Miconazole nitrate, Mucoadhesive thermosensitive pluronic lecithin organogel.