ABSTRACT

The present study was designed to evaluate the polymeric effect of METHOCEL K100MCR on the sustained release drug product of Carvedilol, an antihypertensive drug and also used for congestive heart failure. Carvedilol matrix tablets were formulated by direct compression method using METHOCEL K100MCR polymer in various percentage. Physical parameters were tested and the dissolution procedure was performed by using USP paddle method for eight hours to examine the release kinetics. In the study, METHOCEL K100MCR polymer was found to cause the strong retardation of the drug release. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer equation. Polymer type, polymer level and physicochemical properties of drug functionalize on the release kinetics of sustained release Carvedilol formulation. With a satisfactory result this sustained release Carvedilol drug can be marketed to treat patient ensuring proper healthcare.

Key words: Carvedilol, Sustained release drug, Methocel, Matrix tablet, Formulation, Higuchi equation, Korsmeyer-Peppas.