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ANXIOLYTIC AND CNS DEPRESSANT ACTIVITY OF EXTRACTS OBTAINED FROM SEEDS OF ZIZIPHUS RUGOSA

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ABSTRACT Ziziphus rugosais found in India as well as other Asian countries, literature survey revealed that no work has been evaluated for its therapeutic effects against behavioral disorders. In this investigation, the neuropharmacological profile of petroleum ether, chloroform and ethanolic extracts of aerial parts of Ziziphus rugosa Wild was evaluated by using models like; potentiation of phenobarbitone-induced sleeping time, loco motor activity, exploratory behavior pattern, elevated plus maze and hole-board apparatus. The observations and results obtained in this study indicated that Ziziphus rugosa pet ether extract at doses 100mg/kg and 400mg/kg has given the restrained central activity.

Keywords: Ziziphus rugosa, CNS Depressant, Anti-Anxiety, Saponins.

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