| Acne vulgaris is a common chronic inflammatory disease of the skin which is usually seen in adolescence. In
hyperseborrhea, follicular hyperkeratinization, Propionibacterium acnes colonization and inflammation are found to be
responsible in the pathogenesis of acne, the exact mechanisms are unknown. Vitamin A and E are basic antioxidants vital
for health. Zinc is also an essential element for human. But these parameters of the effects on skin are not fully
understood. The aim of the present study to evaluate plasma levels of vitamin A, E and zinc in acne patients in relation to
the severity of the disease. In the present study total 100 acne patients who were referred to our clinic, all new diagnosed
and 50 age and sex matched healthy volunteers as control group. All patients are assessed according to standard grading
system. We can divide into 3 groups named as mild, moderate, severe and very severe. In our study, Acne patients further
grouped as group 1 consist of patients with mild to moderate disease; and group 2 consist of patients with severe to very
severe acne. The patients with the controls and group 1 with group 2 were compared. The level of vitamin E, vitamin A
and zinc were significantly lower than the control group (Table 1, p 0.001). When the patient group is compared among
each other there was no statistically significant difference for plasma vitamin A levels between group 1 and 2 whereas
vitamin E and zinc levels were significantly low in group 2 than group 1. Thus there was a negative correlation between
acne severity and vitamin E and zinc levels. Our study focused and stated that significance and incorporation of different
supplements in diet to patients with acne. Our study finally concluded that supportive dietary measures with foods rich in
vitamin A and E and zinc in the acne prophylaxis and treatment.ddd |
