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EFFICACY OF CITRUS ESSENTIAL OIL ON THE GROWTH OF ORAL CANDIDIASIS IN ELDERLY DIABETIC POPULATION - RANDOMIZED PARALLEL GROUP CLINICAL TRAIL

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ABSTRACT
This randomized control 2 month’s intervention clinical trial was done with objective to evaluate the effect of 0.2% chlorhexidine gluconate, and 2% citrus essential oils (EO) (C. limonum or lemon) mouthwashes on the growth of oral candidiasis in elderly long standing diabetic population. This pilot double-blind parallel design study was done with 20 subjects in each group. The selected subjects were randomly allocated into 2 groups, group A- using 0.2% chlorhexidine mouthwash, group B- 2% mouthwash prepared from C. limonum EO. At the beginning and end (after 60 days) of the study non-stimulated saliva samples were obtained and C. albicans colonies from the saliva samples were counted and calculated as the number of colony-forming units (CFUs). Both baseline and postoperative data were compared using appropriate statistical analysis. The results of the present study indicate that there was significant decrease in the number of colony-forming units of C. albicans in both the groups (chlorhexidine & lemon) compared to baseline count. However chlorhexidine showed better results as compared to lemon group. It was concluded that 2% lemon mouthwash can act as an alternative herbal drug formulation which is natural biodegradable and safe that is effective against C albicans.
Key words: C. albicans, Elderly diabetic, C. limonum, Essential oil, Mouthwash.

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