ABSTRACT
To study the effect of neostigmine as an adjuvant to bupivacaine in spinal anaesthesia on onset and duration of sensory and motor block , duration of post-operative analgesia, perioperative hemodynamic parameters and complications. 80 patients of ASA I & II scheduled for lower abdominal or lower limb surgery were included in double blind randomized comparison of 40 patients in each group. Group A patients were given injection neostigmine 100 μg + bupivacaine and group B patients were given only bupivacaine. We recorded time of onset and duration of sensory and motor block, duration of analgesia, hemodynamic changes and side effects in both groups. Post-operative pain is less in group A (study group) compared to group B (control group) and pain relief is significant highly (p <0.001) in study group. Duration of motor and sensory blockade is also prolonged in study group. Intrathecal neostigmine produces prolonged postoperative analgesia and produces a good sensory and motor for the surgical procedure.
Key words: Intrathecal, Neostigmine, Bupivacaine, Analgesia.