ABSTRACT

                The analysis of the functional state of the enzymatic detoxification of xenobiotics and oxidative modification of proteins in the serum of 60 long livers (study group) and 30 individuals having no long livers in their family trees (control group) was done. It was found that the activity of glutathione peroxidase in all long livers was respectively (0.329 ± 0.18) mmol / (min • mg) (study group), and (0.353 ± 0.17) mmol / (min • mg) (control group). The activity of the enzyme glutathione reductase in long livers (Carpathian region) was 3.17 times higher compared with persons of control group. Tendency to decreased GST activity respectively in long livers (0.305 ± 0.31) mmol / (min • mg ) and control group (0.345 ± 0.18) mmol / (min • mg) was found out. The significant reduction of oxidative modification of protein products of neutral aldehyde and ketone derivatives in study group compared with control one was proved statistically. The intensification of the processes of oxidative modification of proteins in long livers was accompanied by an increase by means of aldehyde and ketone derivatives compared with persons of mature age. These results may indicate better functioning of antiradical protection of long livers compared with persons of old age.

Key words: Long livers, Protein oxidative modifications, Glutathione peroxidase, Glutathione reductase, Glutathione-S-tranferase.