ABSTRACT
The mucoadhesive matrix tablets of ciprofloxacin HCl were fabricated with objective of controlled release and prolonging duration of action. The mucoadhesive polymers used in formulations were tamarind seed polysaccharide (TSP), HPMC K-100 and Xanthan gum. These formulations were characterized for physiochemical parameters, in vitro adhesion retention time, in vitro mucoadhesive strength, swelling index and drug release. The modified in vitro assembly was used to measure the mucoadhesive strength of tablets with fresh goat stomach mucosa as a model tissue. Finally the results were compared between formulations made by TSP and HPMC K-100, Xanthan gum. The best mucoadhesive performance and in vitro drug release profile were exhibited by the tablets containing 30% TSP coded by T5, 35% HPMC K-100 coded by H6 and 35% Xanthan gum coded by X6. These formulations showed drug release at 12 hours 98.86 %, 97.57 % and 97.5% respectively as well as maintained excellent matrix integrity during the period of study. These formulations were more comfortable to the user due to less erosion, optimum swelling index.
Key words: Mucoadhesive matrix tablet, Tamarind seed polysaccharide, Bio adhesive Strength, In vitro adhesion retention time, Ciprofloxacin HCl.