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Aim of the study: ischemic stroke is a serious pathology, responsible for many situations of chronic disability. Taking a very early treatment can prevent complications and reduce sequelae. Aspirin is one of the major treatments after stroke and prevents recurrence. Taking a lifelong treatment requires medication adherence and patient compliance. Clinical pharmacists inform patient at the bedside about his treatment. The aim of this study is to evaluate if the pharmacist could improve patient knowledge about benefits and risks of aspirin and in consequence potentially improve patient’s compliance. Methods: prospective study was conducted in the Neurovascular Care Unit during one year. Pharmacists and physicians created a booklet about aspirin and a patient questionnaire (7 questions). These tools were used during the patient interview conducted by clinical pharmacists at the bedside in the care unit. Questions were about general knowledge of aspirin and the last question was about the satisfaction of delivered aspirin information during hospitalization. The booklet was used to inform patient and complement pharmacist interview. At the end of the interview the same 7 questions were asked again. Results: 73 patients were interviewed. Pharmaceutical interviews can improve significantly the patient knowledge about aspirin (p<0.01). After the pharmaceutical information, the patient dissatisfaction decreased significantly (p<0.001). Conclusion: this booklet is one way to optimize patient treatment by enabling them to better understand their pathology. The clinical pharmacist can play a role in optimizing the management of adverse effects by informing the patient and by ensuring adherence to treatment. The purpose of these interviews with the patient is to maximize the compliance or patient’s adherence to treatment to ensure its efficiency and limit the adverse effects. The medical staff and clinical pharmacists are able to support the patient for the fulfillment of preventive measurements after cerebral stroke.ddd